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國立清華大學化學系 Department of Chemistry
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林竣偉

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職稱：
助理教授                                                    
學歷：
美國賓州大學化學系博士 (2016)
國立臺灣大學碩士 (2008)
國立交通大學學士 (2006)
辦公室位置：
研究室位置：
 化學館R202
化學館R203
辦公室分機：
研究室分機：
 (03)5715131 ext 33343
(03)5715131 ext 35612
電子信箱：
 chunweilin@mx.nthu.edu.tw 
個人網站：
 https://www.cwlinlab.com/

經歷：
2022 ~
2018 ~ 2021
國立清華大學助理教授
博士後研究：加州大學柏克萊分校

研究領域：

生物化學、生物物理、物理化學.

運用單分子螢光顯微鏡搭配體外重建的脂質膜平台或單一活體細胞觀測,

  1. 研究膜蛋白及下游蛋白訊號傳遞於單分子層級的機制
  2. 了解不同的Agonist 對於膜蛋白之作用
  3. 探討膜蛋白於免疫細胞識別之相關機制
  4. 開發高效率膜蛋白萃取與體外重建之技術
  5. 應用膜蛋白的二維相變化於蛋白分子二聚化的偵測

期刊論文：
  1. Lin, C.-W.; Nocka, L. M.; Stinger, B. L.; DeGrandchamp, J. B.; Lew, L.J. N.; Alvarez, S; Phan, H. T.; Kondo, Y.; Kuriyan, J*; Groves J. T.*, A Two-component Protein Condensate of the EGFR Cytoplasmic Tail and Grb2 Regulates Ras Activation by SOS at the Membrane. Proc. Natl. Acad. Sci U.S.A. 2022, 119(19), e2122531119.
  2. Chen, Z.†; Cao, Y.†; Lin, C.-W.; Alvarez, S.; Oh D.; Yang, P.*; Groves, J. T.*, Nanopore-Mediated Protein Delivery Enabling Three-Color Single-Molecule Tracking in Living Cells. Proc. Natl. Acad. Sci. U.S.A. 2021, 118 (5), e2012229118.
  3. Lin, C.-W.; Mensa, B.; Barniol-Xicota, M.; DeGrado, W. F.; Gai, F., Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy. Angew. Chem. Int. Ed. 2017, 56, 5283.
  4. Hilaire, M. R.†; Ahmed, I. A.†; Lin, C.-W.; Gai, F., Blue Fluorescent Amino Acid for Biological Spectroscopy and Microscopy. Proc. Natl. Acad. Sci. U.S.A. 2017, 114 (23), 6005.
  5. Lin, C.-W.; Gai, F. Microscopic Nucleation and Propagation Rates of an Alanine-Based α-helix.  PCCP. 2017, 19, 5028-5036.
  6. Lin, C.-W.; Culik, R. M.; Gai, F., Using VIPT-Jump to Distinguish Between Different Folding Mechanisms: Application to BBL and a Trpzip. J. Am. Chem. Soc. 2013, 135 (20), 7668-7673. 
  7. Lin, C.-W.; Chou, P.-T.*; Liao, Y.-H.; Lin, Y.-C.*; Chen, C.-T.; Chen, Y.-C.; Lai, C.-H.; Chen, B.-S.; Liu, Y.-H.; Wang, C.-C.; Ho, M.-L.*, Photoisomerization of a Maleonitrile-Type Salen Schiff Base and Its Application in Fine-Tuning Infinite Coordination Polymers. Chemistry – A European Journal 2010, 16 (12), 3770-3782.
  8. Chen, C.-L.; Lin, C.-W.; Hsieh, C.-C.; Lai, C.-H.; Lee, G.-H.; Wang, C.-C.; Chou, P.-T., Dual Excited-State Intramolecular Proton Transfer Reaction in 3-Hydroxy-2-(pyridin-2-yl)-4H-chromen-4-one. J. Phys. Chem. A 2008, 113 (1), 205-214.
  9. Hwang, K.-C.; Chen, J.-L.; Chi, Y.*; Lin, C.-W.; Cheng, Y.-M.; Lee, G.-H.; Chou, P.-T.*; Lin, S.-Y.; Shu, C.-F.*, Luminescent Osmium(II) Complexes with Functionalized 2-Phenylpyridine Chelating Ligands: Preparation, Structural Analyses, and Photophysical Properties. Inorg. Chem. 2008, 47 (8), 3307-3317.
  10. Chen, J.-L.; Chang, S.-Y.; Chi, Y.*; Chen, K.; Cheng, Y.-M.; Lin, C.-W.; Lee, G.-H.; Chou, P.-T.*; Wu, C.-H.; Shih, P.-I.; Shu, C.-F.*, PtII Complexes with 6-(5-Trifluoromethyl-Pyrazol-3-yl)-2,2′-Bipyridine Terdentate Chelating Ligands: Synthesis, Characterization, and Luminescent Properties. Chemistry – An Asian Journal 2008, 3 (12), 2112-2123.
  11. Wang, C.-C.*; Lin, W.-Z.; Huang, W.-T.; Ko, M.-J.; Lee, G.-H.; Ho, M.-L.; Lin, C.-W.; Shih, C.-W.; Chou, P.-T.*, New Supramolecular Isomers with 2D 44 Square-grid and 3D 65·8 Frameworks in a One-pot Synthesis; Reversible Solvent Uptake and Intriguing Luminescence Properties. Chem. Commun. 2008, (11), 1299-1301.
  12. Song, Y.-H.; Chiu, Y.-C.; Chi, Y.*; Chou, P.-T.*; Cheng, Y.-M.; Lin, C.-W.; Lee, G.-H.; Carty, A. J., Synthesis, Characterization, and Photophysical Properties of Luminescent Gallium and Indium Complexes Constructed using Tridentate 6-Azolyl-2,2′-bipyridine Chelates. Organometallics 2007, 27 (1), 80-87.
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