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國立清華大學化學系 Department of Chemistry
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洪嘉呈

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職稱：
教授                                                                  
學歷：
美國紐約州立大學石溪校區博士(2004)
國立清華大學碩士(1994)
國立台灣師範大學學士(1992)
辦公室位置：
化學館R402
辦公室分機：
實驗室分機：
 (03)5715131 ext 35635
(03)5715131 ext 33366
電子信箱：
個人網站：

經歷：
2019 ~ 
2011 ~ 2019
2006 ~ 2011
2004 ~ 2006
國立清華大學教授
國立清華大學副教授
國立清華大學助理教授
博士後研究：美國威斯康辛大學麥迪遜校區

研究領域：
胜肽化學、設計與結構，蛋白質摺疊與設計

代表性期刊論文與著作：(Since 2006)
  1. K. Y. Huang, C. C. Yu, and J. C. Horng*. Conjugating catalytic polyproline fragments with a self-assembling peptide produces efficient artificial hydrolases. Biomacromolecules 2020, 21, 1195-1201.
  2. T. Y. Chen, W. J. Cheng, J. C. Horng, and H. Y. Hsu*. Artificial peptide-controlled protein release of Zn2+-triggered, self-assembled histidine-tagged protein microparticle. Colloids Surf. B 2020, 187, 110644.
  3. K. Y. Huang and J. C. Horng*. Impacts of the terminal charged residues on polyproline conformation. J. Phys. Chem. B 2019, 123, 138-147.
  4. W. H. Tseng, M. C. Li, J. C. Horng, and S. K. Wang*. Strategy and effects of polyproline peptide stapling by copper(I)-catalyzed alkyne-azide cycloaddition reaction. ChemBioChem 2019, 20, 153-158.
  5. Y. H. Ting, H. J. Chen, W. J. Cheng, and J. C. Horng*. Zinc(II)-histidine induced collagen peptide assemblies: Morphology modulation and hydrolytic catalysis evaluation. Biomacromolecules 2018, 19, 2629-2637.
  6. C. Y. Chen*, T. P. Ko, K. F. Lin, B. L. Lin, C. H. Huang, C. H. Chiang, J. C. Horng. NADH/NADPH bi-cofactor-utilizing and thermoactive ketol-acid reductoisomerase from Sulfolobus acidocaldarius. Sci. Rep. 2018, 8, 7176
  7. P. Y. Hung, Y. H. Chen, K. Y. Huang, C. C. Yu, and J. C. Horng*. Design of polyproline-based catalysts for ester hydrolysis. ACS Omega 2017, 2, 5574-5581.
  8. Y. C. Lai, C. Y. Lin, M. R. Chung, P. Y. Hung, J. C. Horng*, I. C. Chen, and L. K. Chu*. Distance-dependent excited –state electron transfer from tryptophan to gold nanoparticles through polyproline helices. J. Phys. Chem. C 2017, 121, 4882-4890.
  9. C. H. Chiang, Y. H. Fu, and J. C. Horng*. Formation of AAB-type collagen heterotrimers from designed cationic and aromatic collagen-mimetic peptides: Evaluation of the C-terminal cation-p interactions. Biomacromolecules 2017, 18, 985-993.
  10. P. W. Huang, J. M. Chang, and J. C. Horng*. Effects of glycosylated (2S,4R)-hydroxyproline on the stability and assembly of collagen triple helices. Amino Acids 2016, 48, 2765-2772.
  11. C. H. Chiang and J. C. Horng*. Cation-p interaction induced folding of AAB-type collagen heterotrimers. J. Phys. Chem. B 2016, 120, 1205-1211.
  12. Y. J. Lin, L. K. Chu, and J. C. Horng*. Effects of the terminal aromatic residues on polyproline conformation: thermodynamic and kinetic studies. J. Phys. Chem. B 2015, 119, 15796-15806.
  13. K. Y. Huang and J. C. Horng*. Modulating the affinities of phosphopeptides for the human Pin1 WW domain using 4-substituted proline derivatives. Biochemistry 2015, 54, 6186-6194.
  14. W. L. Hsu, T. C. Shih, and J. C. Horng*. Folding stability modulation of the villin headpiece helical subdomain by 4-fluorophenylalanine and 4-methylphenylalanine. Biopolymers 2015, 103, 627-637.
  15. J. R. Hwu, M. Kapoor, R. Y. Li, Y. C. Lin, J. C. Horng, and S. C. Tsay. Synthesis of nucleobase-functionalized carbon nanotubes and their hybridization with single-stranded DNA. Chem. Asian J. 2014, 9, 3408-3412.
  16. Y. J. Lin, C. H. Chang, and J. C. Horng*. The impact of 4-thiaproline on polyproline conformation. J. Phys. Chem. B 2014, 118, 10813-10820.
  17. Y. J. Lin and J. C. Horng*. Impacts of terminal (4R)-fluoroproline and (4S)-fluoroproline residues on polyproline conformation. Amino Acids 2014, 46, 2317-2324.
  18. H. C. Tang, Y. J. Lin, and J. C. Horng*. Modulating the folding stability and ligand binding affinity of Pin1 WW domain by proline ring puckering. Proteins 2014, 82, 67-76.
  19. C. C. Hong, C. P. Chen, J. C. Horng, and S. Y. Chen. Point-of care protein sensing platform based on immuno-like membrane with molecularly-aligned nanocavities. Biosens. Bioelectron. 2013, 50, 425-430.
  20. M. C. Lu, L. L. Chiu, L. Y. Chiu, C. Y. Lin, and J. C. Horng*. Highly selective and water-soluble peptidyl chemosensors for copper(II) and mercury(II) ions based on a β-hairpin structure. Anal. Methods 2013, 5, 1702-1707.
  21. W. Hsu, Y. L. Chen, and J. C. Horng*. Promoting self-assembly of collagen-related peptides into various higher-order structures by metal-histidine coordination. Langmuir 2012, 28, 3194-3199.
  22. Z. S. Lin, F. C. Lo, C. H. Li, C. H. Chen, W. N. Huang, I. J. Hsu, J. F. Lee, J. C. Horng, and W. F. Liaw. Peptide-bound dinitrosyliron complexes (DNICs) and neutral/reduced-form Roussin’s red esters (RREs/rRREs): understanding nitrosylation of [Fe-S] clusters leading to the formation of DNICs and RREs using a de novo design strategy. Inorg. Chem. 2011, 50, 10417-10431.
  23. C. C. Chen, W. Hsu, T. C. Kao, and J. C. Horng*. Self-assembly of short collagen-related peptides into fibrils via cation-p interactions. Biochemistry 2011, 50, 2381-2383.
  24. C. C. Chen, W. Hsu, K. C. Hwang, J. R. Hwu, C. C. Lin, and J. C. Horng*. Contribution of cation-p interactions to the collagen triple helix stability. Arch. Biochem. Biophys. 2011, 508, 46-53.
  25. Y. S. Chen, C. C. Chen, and J. C. Horng*. Thermodynamic and kinetic consequences of substituting glycine at different positions in a Pro-Hyp-Gly repeat collagen model peptide. Biopolymers (Peptide Science) 2011, 96, 60-68.
  26. T. Y. Zheng, Y. J. Lin, and J. C. Horng*. Thermodynamic consequences of incorporating 4-substituted proline derivatives into a small helical protein. Biochemistry 2010, 49, 4255-4263.
  27. Y. C. Chiang, Y. J. Lin, and J. C. Horng*. Stereoelectronic effects on the transition barrier of polyproline conformational interconversion. Protein Sci. 2009, 18, 1967-1977.
  28. Y. W. Chiang, T. Y. Zheng, C. J. Kao, and J. C. Horng. Determination of interspin distance distributions by CW-ESR is a single linear inverse problem. Biophys. J. 2009, 97, 930-936.
  29. J. H. Cho, S. Sato, J. C. Horng, B. Anil, and D. P. Raleigh. Electrostatic interactions in the denatured state ensemble: their effect upon protein folding and protein stability. Arch. Biochem. Biophys. 2008, 469, 20-28.
  30. J. C. Horng, F. W. Kotch, and R. T. Raines. Is glycine a surrogate for a D-amino acid in the collagen triple helix? Protein Sci. 2007, 16, 208-215.
  31. J. C. Horng, A. J. Hawk, Q. Zhao, E. S. Benedict, S. D. Burke, and R. T. Raines. Macrocyclic scaffold for the collagen triple helix. Org. Lett. 2006, 8, 4735-4738
  32. Y. Li, J. C. Horng and D. P. Raleigh. pH Dependent thermodynamic and amide exchange studies of the C-terminal domain of the ribosomal protein L9: implications for unfolded state structure. Biochemistry 2006, 45, 8499-8506.
  33. J. C. Horng and R. T. Raines. Stereoelectronic effects on polyproline conformation. Protein Sci. 2006, 15, 74-83

 

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