謝興邦

職稱：合聘教授
最高學歷：美國紐約州立大學石溪分校博士
辦公室位置：國家衛生研究院/竹南院區：苗栗縣竹南鎮科研路35號
辦公室分機：037-246-1666轉35708
電子信箱：hphsieh@nhri.org.tw
個人網站：http://www.nhri.org.tw/nhri_org/dp/main4_PI_HP.htm

研究專長：

藥物化學、新藥開發、化學生物

期刊論文：

2009

1.Coumar, M. S.; Leou, J. S.; Shukla, P.; Wu, J. S.; Dixit, A. K.; Lin, W. H.; Chang, C. Y.; Lien, T. W.; Tan, U. K.; Chen, C. W.; Hsu, J. T.; Chao, Y. S. Wu, S. Y.^*; Hsieh, H. P.^*"Structure-based drug design of novel Aurora kinase A inhibitors: Structural basis for potency and specificity", J. Med. Chem. Accepted, 2008 (SCI: 4.895) (NSC95-2113-B-400-001- MY3 and NSC-95-2752-B-007-002-PAE) (corresponding author)

2.Coumar, M. S.; Cheung, A. C. H.; Chang, J. Y.; Hsieh, H. P.^* "Advances in Aurora Kinase Inhibitor Patents" Expert Opinion on Therapeutic Patents, Accepted, 2008. (SCI: 1.589) (corresponding author)

3.Hung, H. C.; Tseng, C. P.; Yang, J. M.; Ju, Y. W.; Tseng, S. N.; Chen, Y. F.; Chao, Y. S.; Hsieh, H. P.; Shih, S. R.; Hsu, J. T. "Aurintricarboxylic Acid Inhibits Influenza Virus Neuraminidase", Antiviral Res. 2008, Nov 14. [Epub ahead of print] (SCI: 3.358)

2008

4.Reddy, G. R.; Kuo, C. C.; Tan, U. K.; Coumar, M. S.; Chang, C. Y.; Chiang, Y. K.; Lai, M. J.; Yeh, J. Y.; Wu, S. Y.; Chang, J. Y.; Liou, J. P.^*; Hsieh, H. P.^* "Synthesis and Structure-Activity Relationships of 2-Amino-1-aroylnaphthalene and 2-Hydroxy-1-aroyl naphthalenes as Potent Antitubulin Agents", J. Med. Chem. 51, 8163-8167. (SCI: 4.895) (NSC95-2113-B-400-001-MY3) (corresponding author)

5.Liou, J. P.; Wu, Z. Y.; Kuo, C. C.; Chang, C. Y.; Lu, P. Y.; Chen, C. M.; Hsieh, H. P.^*; Chang, J. Y.^* "Discovery of 4-Amino and 4-Hydroxy-1-Aroylindoles as Potent Tubulin Polymerization Inhibitors", J. Med. Chem.2008, 51, 4351-4355. (NSC95-2113-B-400-001- MY3) (SCI: 4.895) (corresponding author)

6.Chou, Y. C.; Prakash, E.; Huang, C. F.; Lien, T. W.; Chen, X.; Su, I. J.; Chao, Y. S.; Hsieh, H. P.^*; Hsu, J. T.^* "Bioassay-Guided Purification and identification of PPAR Agonists from Chlorella Sorokiniana", Phytother. Res. 2008, 22, 605-613. (SCI: 1.43) (corresponding author)

7.Lin, W. H.; Song, J. S.; Chang, T. Y.; Chang, C. Y.; Fu, Y. N.; Yeh, C. L.; Wu, S. H.; Huang Y. W.; Fang, M. Y.; Lien, T. W.; Hsieh, H. P.; Chao, Y. S.; Huang, S. F.; Tsai, S. F.; Wang, L. M.; Hsu, J. T.^*; Chen, Y. R.^* "A Cell-based High-throughput Screen for Epidermal Growth Factor Receptor Pathway Inhibitors", Anal. Biochem. 2008, 377, 89-94. (SCI: 3.002)

8.Su, C. T.; Hsu, J. T; Hsieh, H. P.; Lin, P. H.; Chen, T. C.; Kao, C. L.; Lee, C. N.; Chang, S. Y.^*"Anti-HSV Activity of Digitoxin and its Possible Mechanisms", Antiviral Res. 2008,79, 62-70. (SCI: 3.358)

9.Chou, C. Y.; Chien, C. H.; Han, Y. S.; Prebanda, M. T.; Hsieh, H. P.; Turk, B.; Chang, G. G.; Chen, X.^*"Thiopurine Analogues Inhibit Papain-like Protease of Severe Acute Respiratory Syndrome Coronavirus", Biochem. Pharmacol. 2008, 75, 1601-1609. (SCI: 4.006)

10.Romagnoli, R.; Baraldi, P. G.; Sarkar, T.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Preti, D.; Tabrizi, M. A.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Zonta, N.; Balzarini, J.; Brancale, A.; Hsieh, H. P.; Hamel, E.^* "Synthesis and Biological Evaluation of 1-Methyl- 2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors", J. Med. Chem.2008, 51, 1464-1468. (NSC95-2113-B-400-001-MY3) (SCI: 4.895) (citation: 1)

11.Coumar, M. S.; Wu, J. S.; Leou, J. S.; Tan, U. K.; Chang, C. Y.; Chang, T. Y.; Lin, W. H.; Hsu, J. T.; Chao, Y. S.; Wu, S. Y.^*; Hsieh, H. P.^* "Aurora Kinase A Inhibitors: Identification, SAR Exploration and Molecular Modeling of 6,7-Dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d] pyrimidine-5,8-dione Scaffold", Bioorg. Med. Chem. Lett. 2008, 18, 1623-1627. (SCI: 2.604) (corresponding author) (NSC95-2113-B-400-001-MY3)

12.Chittimalla, S. K.; Chang, T. C.; Liu, T. C.; Hsieh, H. P.^*; Liao, C. C.^* "Reactions of 2-Hydroxybenzophenones with Corey-Chaykovsky Reagent", Tetrahedron 2008, 64, 2586-2595. (SCI: 2.869) (corresponding author) (NSC95-2113-B-400-001-MY3)

13.Kao, Y. H.; Hsieh, H. P.; Chitlimalla, S. K.; Pan, W. Y.; Kuo, C. C.; Tsai, Y. C.; Lin, W. H.; Chuang, S. E.; Chang, J. Y.^*"A Novel Peroxisome Proliferator-activated Receptor Alpha/Gamma Agonist, BPR1H0101, Inhibits Topoisomerase II Catalytic Activity in Human Cancer Cells", Anti-cancer Drugs, 2008, 19, 151-158. (SCI: 2.357)

14.Shiao, H. Y., Hsieh, H. P.^*; Liao, C. C.^*"First Total Syntheses of (+/-)-Annuionone B and (+/-)-Tanarifuranonol", Org. Lett. 2008, 10, 449-452. (SCI: 4.802) (corresponding author) (NSC95-2113-B-400-001-MY3) (citation: 1)

2007

15.Liou, J. P.; Wu, C. Y.; Hsieh, H. P.; Chang, C. Y.; Chen, C. M.; Kuo, C. C.; Chang, J. Y.^* "4- and 5-Aroylindoles as Novel Classes of Potent Antitubulin Agents", J. Med. Chem.2007, 50, 4548-4552. (SCI: 4.895) (citation: 3)

16.Chen, C. C.; Chen, L. T.; Tsou, T. C.; Pan, W. Y.; Kuo, C. C.; Liu, J. F.; Yeh, S. C.; Tasi, F. Y.; Hsieh, H. P.; Chang, J. Y.^* "Combined Modalities of Resistance in an Oxaliplatin-Resistant Human Gastric Cancer Cell Line with Enhanced Sensitivity to 5-Fluorouracil", Br. J. Cancer 2007, 97, 334-344. (SCI: 4.635) (citation: 2)

17.Hsieh, H. P.; Hsu, J. T.^{*"Strategies of Development of Antiviral Agents Directed against Influenza Virus Replication", Curr. Pharm. Design 2007, 13, 3531-3542. (SCI: 4.868) (citation: 8)}

18.Yao, H. T.; Wu, Y. S.; Chang, Y. W.; Hsieh, H. P.; Chen, W. C.; Lan, S. J.; Chen, C. T.; Chao, Y. S.; Chang, L.; Sun, H. Y.; Yeh, T. K.^* "Biotransformation of BPR0L075, A Novel Antimicrotubule Agent, By Mouse, Rat, Dog And Human Liver Microsomes", Drug Metab. Dispos. 2007, 35, 1042-1049. (SCI: 3.907)

19.Coumar, M. S.; Chang, C. N.; Chen, C. T.; Chen, X.; Chien, C. H.; Tsai, T. Y.; Cheng, J. H.; Wu, H. Y.; Han, C. H.; Wu, S. H.; Huang, Y. W.; Hsu, T.; Hsu, L. J.; Chao, Y. S.; Hsieh, H. P.^*; Jiaang, W. T.^* "3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)- 2-oxo-ethylamino]-3-methyl-butyramide Analogues as Selective DPP-IV Inhibitors for the Treatment of Type-II Diabetes",Bioorg. Med. Chem. Lett. 2007, 17, 1274-1279. (SCI: 2.604) (corresponding author)(citation: 1)

20.Chen, C. N.; Huang, H. H.; Wu, C. L.; Lin, C. P. C.; Hsu, J. T. A.; Hsieh, H. P.; Chuang, S. E.; Lai, G. M.^*"Isocostunolide, a Sesquiterpene Lactone, Induces Mitochondrial Membrane Depolarization and Caspase-dependent Apoptosis in Human Melanoma Cells", Cancer Lett. 2007,246, 237-252. (SCI: 3.398) (citation: 5)

21.Chang Y. W.; Chen, W. C.; Lin, K. T.; Chang, L., Yao, H. T.; Hsieh, H. P.; Lan, S. J.; Chen, C. T.; Chao, Y. S.; Yeh, T. K.^* "Development and Validation of a Liquid Chromatography-tandem mass Spectrometry for the Determination of BPR0L075, a Novel Antimicrotuble Agent, in Rat Plasma: Application to a Pharmacokinetic Study", J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 846, 162-168. (SCI: 2.935) (citation: 1)

2006

22.Chang, J. Y.; Hsieh, H. P.; Chang, C. Y.; Hsu, K. S.; Chiang, Y. F.; Chen, C. M.; Kuo, C. C.; Liou, J. P. "7-Aroyl-aminoindoline-1-sulfonamides as a Novel Class of Potent Antitubulin Agents", J. Med. Chem.2006,49, 6656-6659. (SCI: 4.895) (citation: 3)

23.Mahindroo, N.; Peng, Y. H.; Lin, C. H.; Tan, U. K.; Prakash, E.; Lien, T. W.; Lu, I. L.; Lee, H. J.; Hsu, J. T. A.; Chen, X.; Liao, C. C.; Lyu, P. C.; Chao, Y. S.; Wu, S. Y.^*; Hsieh, H. P.^*"Structural Basis for the Structure-Activity Relationships of Peroxisome Proliferator-Activated Receptor Agonists", J. Med. Chem.2006, 49, 6421-6424. (SCI: 4.895)(corresponding author) (citation: 7)

24.Liou, J. P.; Mahindroo, N.; Chang, C. W.; Guo, F. M.; Lee, S. W. H.; Tan, U. K.; Yeh, T. K.; Kuo, C. C. ; Chang, Y. W.; Lu, P. H.; Tung, Y. S.; Lin, K. T.; Chang, J. Y.^*; Hsieh, H. P.^* "Structure-Activity Relationship Studies of 3-Aroylindoles as Potent Antimitotic Agents",ChemMedChem, 2006, 1, 1106-1118. (SCI: 2.825)(corresponding author) (citation: 8)

25.Lu, I. L.; Mahindroo, N.; Liang, P. H.; Peng, Y. H.; Kuo, C. J.; Tsai, K. C.; Hsieh, H. P.^*; Chao, Y. S.; Wu, S. Y.^* "Structure-based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease",J. Med. Chem. 2006, 49, 5154-5161. (SCI: 4.895) (corresponding author) (citation: 19)

26.Chang, Y. W.; Yeh, T. K.; Lin, K. T.; Chen, W. C.; Yao, H. T.; Lan, S.. J.; Wu, Y. S.;Hsieh, H. P.; Chen, C. M.; Chen, C. T.^* "Pharmacokinetics of Anti-SARS-CoV Agent Niclosamide and Its Analogs in Rats", J. Food Drug Analysis, 2006, 14, 329-333. (SCI: 0.568)(citation: 1)

27.Wu, Y. S.; Lin, W. S.; Hsu, J. T. A.^{*(SCI: 4.994) (corresponding author) (citation: 12)};Hsieh, H. P.^*"Antiviral Drug Discovery against SARS-CoV", Curr. Med. Chem. 2006, 13, 2003-2020.

28.Tsai, K. C.; Chen, S. Y.; Liang, P. H.; Lu, I. L.; Mahindroo, N.; Hsieh, H. P.; Chao, Y. S.; Liu, L.; Liu, D.; Lien, W.; Lin, T. H.*; Wu, S. Y.* "Discovery of a Novel Family of SARS-CoV Protease Inhibitors by Virtual Screening and 3D-QSAR Studies", J. Med. Chem. 2006, 49, 3485-3495. (SCI: 4.895) (citation: 16)

29.Mahindroo, N.; Liou, J. P.; Chang, J. Y.^*; Hsieh, H. P.^* "Antitubulin Agents for Treatment of Cancer- A Medicinal Chemistry Update", Expert Opinion on Therapeutic Patents, 2006, 16, 647-691. (SCI: 1.589) (corresponding author) (citation: 12)

30.Lu, I. L.; Huang, C. F.; Peng, Y. H.; Lin, Y. T.; Hsieh, H. P.; Chen, C. T.; Lien, T. W.; Lee, H. J.; Mahindroo, N.; Prakash, E.; Yueh, A.; Chen, H. Y.; Goparaju, C. M.; Chen, X.; Liao, C. C.; Chao, Y. S.; Hsu, J. T.^{*(SCI: 4.895) (NSC 92-2323-B-007-001 and NSC 93-2323-B-007-001) (citation: 26)}; Wu, S. Y.^* "Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities", J. Med. Chem. 2006, 49, 2703-2712.

31.Tsai, T. Y.; Coumar, M. S.; Hsu, T.; Hsieh, H. P.; Chien, C. H.; Chen, C. T.; Chang, C. N.; Lo, Y. K.; Wu, S. H.; Huang, C. Y.; Huang, Y. W.; Wang, M. H.;, Wu, H. Y.;, Lee, H. J.; Chen, X.; Chao, Y. S.; Jiaang, W. T.^{*Bioorg. Med. Chem. Lett. 2006, 16, 3268-3272. (SCI: 2.604) (citation: 8)} "Substituted pyrrolidine-2,4-dicarboxylic Acid Amides as Potent Dipeptidyl Peptidase IV Inhibitors",

32.Mahindroo, N.; Wang, C. C.; Liao, C. C.; Huang, C. F.; Lu, I. L; Lien, T. W.; Peng, Y. H.; Huang, W. J.; Lin, Y. T.; Hsu, M. C.; Lin, C. H.; Tsai, C. H.; Hsu, J. T. A.; Chen, X.; Lyu, P. C.; Chao, Y. S.; Wu, S. Y.^*; Hsieh, H. P.^* "Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists – Design, Synthesis, Structural Biology, and Molecular Docking Studies", J. Med. Chem. 2006, 49, 1212-1216. (SCI: 4.895) (NSC 92-2323-B-007-001 and NSC 93-2323-B-007-001) (corresponding author) (citation: 16)

33.Tsu, H.; Chen, X.; Chen, C. T.; Lee, S. J.; Chang, C. N.; Kao, K. H.; Coumar, M. S.; Yeh, Y. T.; Chien, C. H.; Wang, H. S.; Lin, K. T.; Chang, Y. Y.; Wu, S. H.; Chen, Y. S.; Lu, I. L.; Wu, S. Y.; Tsai, T. Y.; Chen, W. C.; Hsieh, H. P.; Chao, Y. S.; Jiaang, W. T.^* "2-[3-[2-[(2S)-2- Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A Potent, Selective, and Orally Bioavailable Dipeptide-Derived Inhibitor of Dipeptidyl Peptidase IV", J. Med. Chem. 2006, 49, 373-380. (SCI: 4.895) (citation: 5)

34.Hwang, D. R.; Wu, Y. S.; Chang, C. W.; Lien, T. W.; Chen, W. C. Tan, U. K.; Hsu, J. T.^*; Hsieh, H. P.^* "Anti-Hepatitis C Virus Agents: Synthesis and Structure-Activity Relationships Studies of Sesquiterpene Lactones Screened by Hepatitis C Virus Replicon System", Bioorg. Med. Chem. 2006, 14, 83-91. (SCI: 2.662) (corresponding author)(citation: 7)

2005

35.Mahindroo, N.; Huang, C. F.; Peng, Y. H.; Wang, C. C.; Lien, T. W.; Liao, C. C.; Kumar, S.; Huang, W. J.; Chen, C. P.; Hsu, T. A.; Prakash, E.; Peng, C. H.; Lu, I. L; Chang, Y. W.; Chen, W. C.; Chen, C. T.; Goparaju, C. M. V.; Chen, Y. S.; Chen, Y. S.; Lan, S. J.; Yu, M. C.; Chen, X.; Chao, Y. S.; Wu, S. Y.^*; Hsieh, H. P.^* "Novel Indole–based Peroxisome Proliferator-Activated Receptors Agonists: Design, SAR, Structural Biology and Biological Activities", J. Med. Chem. 2005, 48, 8194-8208. (SCI: 4.895) (NSC 92-2323-B-007-001 and NSC 93-2323-B-007-001) (corresponding author) (citation: 24)

36.Chen, C. N.; Lin, C. P. C.; Huang, K. K.; Chen, H. W.; Hsieh, H. P.; Liang, P. H.; Hsu, J. T. A.^* "Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3’-digallate (TF3)",Evid. Based Complement Alternat. Med. 2005, 2, 209-215. (SCI: 2.535) (NSC93-2751- B-400-005-Y) (citation: 19)

37.Hsieh, H. P.^*; Liou, J. P.; Mahindroo, N. "Pharmaceutical Design of Antimitotic Agents Based on Combretastatins", Curr. Pharm. Design, 2005, 11, 1655-1677. (SCI: 4.868)(corresponding author) (citation: 33)

38.Chiu, J. J.^*; Chen, L. J.; Chang, S. F.; Lee, P. L.; Lee, C.I.; Tsai, M. C.; Lee, D. Y.;Hsieh, H. P.; Usami, S.; Chien, S. "Shear Stress Inhibits Smooth Muscle Cell-Induced Inflammatory Gene Expression in Endothelial Cells. Role of NF-{kappa}B", Arterioscler. Thromb. Vasc. Biol. 2005, 25, 963-969. (SCI: 7.221) (citation: 11)

2004

39.Hsu, J. T. A.; Kuo, C. J.; Hsieh, H. P.; Wang, Y. C.; Huang, K. K.; Lin, C. P. C.; Huang, P. F.; Chen, X.; Liang, P. H.^* "Evaluation of Metal-Conjugated Compounds as Inhibitors of 3CL Protease of SARS-CoV", FEBS Lett. 2004, 574, 116-120. (SCI: 3.263) (NSC93-2751-B-400- 005-Y) (citation: 32)

40.Liou, J. P.; Chang, Y. L.; Kuo, F. M.; Chang, C. W.; Tseng, H. Y., Wang, C. C.; Yang, Y. N.; Lee, S. J.^*; Hsieh, H. P.^* "Concise Synthesis and Structure-Activity Relationships of Combretastatin A-4 Analogues, 1-Aroylindoles and 3-Aroylindoles, as Novel Classes of Potent Antitubulin Agents", J. Med. Chem. 2004, 47, 4247-4257. (SCI: 4.895) (corresponding author) (citation: 39)

41.Kuo, C. C.; Hsieh H. P.; Pan, W. Y.; Chen, C. P.; Liou, J. P.; Lee, S. J.; Chang, Y. L.; Chen, L. T.; Chen, C. T.^*; Chang, J. Y.^* "BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo",Cancer Res. 2004, 64, 4621-4628. (SCI: 7.672) (citation: 39)

42.Juang, S.H.; Pan, W. Y.; Kuo, C. C.; Liou, J. P.; Chen, L. T.; Hsieh, H. P.; Chang, J. Y.^* "A Novel Bis-benzylidenecyclopentanone Derivative, BPR0Y007, Inducing a Rapid Caspase Activation Involving Upregulation of Fas (CD95/APO-1) and Wild-type p53 in Human Oral Epidermoid Carcinoma Cells", Biochem. Pharmacol. 2004, 68, 293-303. (SCI: 4.006) (citation: 10)

43.Liou, J. P.; Chang, J. Y.; Chang, C. W.; Chang, C. Y.; Mahindroo, N; Kuo, F. M.;Hsieh, H. P.^* "Synthesis and Structure-Activity Relationship of 3-Amino benzophenones as Antimitotic Agents", J. Med. Chem. 2004, 47, 2897-2905. (SCI: 4.895) (corresponding author) (citation: 33)

44.Wu, C. J.; Jan, J. T.; Chen, C. M.; Hsieh, H. P.; Chao, Y. S.; Liu, H. W.; Liu, C. Y.; Huang, H. W.; Chen, S. C.; Hong, C. F.; Lin, R. K.; Huang, D. R.; Hsu, T. A.^* "Inhibition of SARS-CoV Replication by Niclosamide", Antimicrob. Agents Chemother. 2004, 48, 2693-2696. (SCI: 4.390) (citation: 29)

2003

45.Lin, S. Y; Hsieh, H. P.; Peddinti, R. K.; Liao, C. C.^* "Substituent Effects on Di-p-methane and Aza-di-p-methane Rearrangements of Dibenzo[f,h]quinoxalino Barrelenes",Tetrahedron Lett. 2003, 44, 8761-8764. (SCI: 2.615) (citation: 3)

46.Chang, J. Y.^*; Hsieh, H. P.; Pan, W. Y.; Liou, J. P.; Bey, S. J.; Chen, L. T.; Song, J. S. "Dual Inhibition of Topoisomerase I and Tubulin Polymerization by BPR0Y007, a Novel Cytotoxic Agent", Biochem. Pharmacol. 2003, 65, 2009-2019. (SCI: 4.006) (citation: 10)

47.Hsieh, H. P.^*; Liou, J. P.; Lin, Y. T.; Mahindroo, N.; Chang, J. Y.; Yang, Y. N.; Chern, S. S.; Tan, U. K.; Chang, C. W.; Chen, T. W.; Lin, C. H.; Chang, Y. Y.; Wang, C. C."Structure-Activity and Crystallographic Analysis of Benzophenone Derivatives – the Potential Anticancer Agents", Bioorg. Med. Chem. Lett. 2003, 13, 101-105. (SCI: 2.604)(corresponding author) (citation: 26)

2002

48.Liou, J. P.; Chang, C. W.; Song, J. S.; Yang, Y. N.; Yeh, C. F.; Tseng, H. Y.; Lo, Y. K.; Chang, Y. L.; Chang, C. M.; Hsieh, H. P^* "Synthesis and Structure-Activity Relationship of 2-Aminobenzophenone Derivatives as Antimitotic Agents", J. Med. Chem. 2002, 45, 2556-2562. (SCI: 4.895) (corresponding author) (citation: 41)

1990-1999

49.Hsieh, H. P.; Wu, Y. T.; Chen, S. T.^*; Wang, K. T.^* "Direct Solid Phase Synthesis of Octreotide Conjugates: Precursors for Use as Tumor-Targeted Radiopharmaceuticals", Bioorg. Med. Chem. 1999, 7, 1797-1803. (SCI: 2.662) (citation: 10)

50.Wu, Y. T.; Hsieh, H. P.; Chen, S. T.^*; Wang, K. T.^* "Direct Solid Phase Synthesis of Biologically Active Peptide Alcohols", J. Chin. Chem. Soc. 1999, 46, 135-138. (SCI: 0.643) (citation: 2)

51.Hsieh, H. P.; Wu, Y. T.; Wu, C. Y.; Yu, H. M.; Chen, S. T.^*; Wang, K. T.^* “Facile Solid Phase Synthesis of Octreotide Analogs Using p-Carboxybenzaldehyde as a Novel Linker to Anchor Fmoc-Threoninol to Solid Phase Resins”, Tetrahedron Lett. 1998, 39, 1783-1784. (SCI: 2.615) (citation: 6)

52.Hsieh, H. P.; Wu, Y. T.; Chen, S. T.^*; Wang, K. T.^* “Dihydropyran-2-carboxylic Acid, a New Bifunctional Linker for the Solid Phase Synthesis of Peptides Containing a C-terminal Alcohol”, Chem. Commun. 1998, 649-650. (SCI: 5.141) (citation: 8)

53.Hsieh, H. P.; Chen, S. T.^*; Wang, K. T.^* “Microwave Induced Synthesis of 3,4-Dihydro-2H- pyran-2-carboxaldehyde: A Versatile Linker for Solid Phase Combinatorial Library”,J. Chin, Chem. Soc. 1997, 44, 597-600. (SCI: 0.643) (citation: 7)

54.Hsieh, H. P.; McLaughlin, L. W.^* “Synthesis of Two C-Nucleosides as “Deletion Modified Analogues of dC and dT”, J. Org. Chem. 1995, 60, 5356-5359. (SCI: 3.959) (citation: 32)

55.Hsieh, H. P.; Muller, J. G.; Burrows, C. J.^* “Synthesis and DNA Binding Properties of C3-, C12-, and C24-Substituted Amino-Steroids Derived from Bile Acids”, Bioorg. Med. Chem.1995, 3, 823-838. (SCI: 2.662) (citation: 25)

56.Hsieh, H. P.; Muller; J. G.; Burrows, C. J.^* “The Effect of Structural Changes in New Steroidal Polyamines on their DNA-Binding Properties”, J. Am. Chem. Soc. 1994, 116, 12077-12078. (SCI: 7.696) (citation: 48)

57.Liao,C. C.^*; Lin, S. Y.; Hsieh, H. P.; Yang, P. W. “Photochemistry of Quinoxalinobarrelenes and (Benzo[g]quinoxalino)barrelenes”, J. Chin. Chem. Soc. 1992, 39, 275. (SCI: 0.643)

58.Liao, C. C.^*; Lin, S. Y.; Hsieh, H. P. “Photorearrangement of Some Pyrazinobarrelenes”, Chem. Commun. 1990, 545. (SCI: 5.141) (citation: 3)

專利：

1.Hsieh, H. P.; Liou, J. P.; Chang, J. Y.; Chang, C. W. "Indole Compounds," US6933316, August 23, 2005 – December 12, 2022. 美國發明專利

2.Hsu, T. A.; Hsieh, H. P.; Juan, L. J; Chang, S. Y.; Kuo, Y. H., "Anti-virus compounds," TW I293248, February 11, 2008 – May 21, 2023. 中華民國發明專利

3.Hsieh, H. P.; Tung, Y. S.; Liou, J. P. Chang, J. Y.; Chao, Y. S., "Anti-Tumor Compounds," TWI296195, May 1, 2008 – December 27, 2025. 中華民國發明專利

4.Jiaang, W. T; Chen, X.; Wu, S. Y.; Chao, Y. S.; Hsieh, H. P.; "Pyrrolidine Compounds," TW I299039, July 21, 2008 – March 9, 2025. 中華民國發明專利

5.Jiaang, W. T; Chen, X.; Wu, S. Y.; Hsieh, H. P.; Chao, Y. S. "Pyrrolidine Compounds," KR7038951, April 12, 2008 - August 28, 2026. 韓國發明專利

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