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國立清華大學化學系 Department of Chemistry
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江昀緯

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職稱：
教授                                             
學歷：
美國康乃爾大學博士 (2006)
美國康乃爾大學碩士 (2001)
國立中山大學學士 (1998)
辦公室位置：
化學館B14
辦公室分機：
實驗室分機：
(03)5715131 ext 33345
(03)5715131 ext 33346
電子信箱：
個人網站：

經歷：
2017~
2021~2024
2015~2021 
2012~2017
2007~2012
2006~2007
國立清華大學教授
國立清華大學化學系系主任
國立清華大學化學系副主任
國立清華大學副教授
國立清華大學助理教授
博士後研究：美國康乃爾大學 (2006~2007)

研究領域：
物理化學、生物物理、生醫分析、電子自旋共振、膜蛋白

本實驗室從事物理化學跨領域研究，利用光譜、磁共振、螢光、顯微鏡等技術探究分子運動，在分子層次描述生物巨分子、分子聚合體的動力學反應與行為、並進行分子動力學計算。實驗室也從事大量生物醫學、細胞膜蛋白的生醫分析與應用。

代表著作：
 
A. Biophysics/Apoptosis/Membrane Proteins
A1
 		 C.C. Cheng, R.F. Tsai, C.K. Lin, K.T. Tan, V. Kalendra, M. Simenas, C.W. Lin*, and Y.W. Chiang*, In-Cell DEER Spectroscopy of Nanodisc-Delivered Membrane Proteins in Living Cell Membranes, JACS Au, 4 (2024) 3766-3770.
A2
 		 P.S. Yeh, C.C. Li, Y.S. Lu, and Y.W. Chiang*, Structural Insights into the Binding and Degradation Mechanisms of Protoporphyrin IX by the Translocator Protein TSPO, JACS Au, 3 (2023) 2918-2929.
A3

 		 D T.-W. Wang, T. Y.-C. Tang, C.T. Kuo, Y.T. Yu, E. H.-L. Chen, M.T. Lee, R.F. Tsai, H.Y. Chen, Y.W. Chiang*, and R. P.-Y. Chen*, Cholesterol Twists the Transmembrane Di-Gly Region of Amyloid-Precursor Protein, PNAS Nexus, 2 (2023) 162.
A4
 		 C.L. Hung, H.H. Chang, S.W. Lee, Y.W. Chiang*, Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes, Cell Death & Differentiation, 28 (2021) 1910-1925.
A5

 		 C.C.Li, T.Y.Kao, C.C.Cheng, Y.W. Chiang*, Structure and regulation of the BsYetJ calcium channel in
lipid nanodiscs, Proceedings of the National Academy of Sciences (PNAS), 117 (2020). 30126-
30134.
A6

 		 Y.J. Lan, P.S. Yeh, T.Y. Kao, Y.C. Lo, S.C. Sue, Y.W. Chen, D.W. Hwang*, Y.W. Chiang*, Anti-apoptotic
BCL-2 regulation by changes in dynamics of its long unstructured loop, Communications Biology,
3 (2020) 668.
A7
 		 R.F. Tsai, N.C. Lin, T.Y. Kao, Y.H. Kuo, F.C. Lo, W.F. Liaw, Y.W. Chiang*, Nitrosylation of the Diiron Core Mediated by the N Domain of YtfE, Journal of Physical Chemistry Letters, 11 (2020) 8538-8542.
A8
 		 Y.C. Lai, C.C. Li, T.C. Sung, C.W. Chang, Y.J. Lan, and Y.W. Chiang*, The Role of Cardiolipin in Promoting the Membrane Pore-forming Activity of BAX Oligomers, BBA Biomembranes, 1861 (2019) 268-280.
 
B. Physical Chemistry/Water Dynamics/ESR Simulations
B1

 		 T.Y. Kao and Y.W. Chiang*, DEERefiner-assisted Structural Refinement Using Pulsed Dipolar
Spectroscopy: A Study on Multidrug Transporter LmrP, Physical Chemistry Chemical Physics, 25
(2023) 24508-24517.
B2
 		 P.S. Ho, T.Y. Kao, C.C. Li, Y.J. Lan, Y.C. Lai, and Y.W. Chiang*, Nanodisc Lipids Exhibit Singular Behaviors Implying Critical Phenomena, Langmuir, 38 (2022) 15372-15383.
B3

 		 T.Y. Kao, C.L. Hung, Y.J. Lan, S.W. Lee, and Y.W. Chiang*, A Simple Cryoprotectant-Free Method To Advance Pulsed Dipolar ESR Spectroscopy for Capturing Protein Conformational Ensembles, The Journal of Physical Chemistry B, 126 (2022) 423-429.
B4
 		 Y.C. Lai, Y.H. Kuo, and Y.W. Chiang*, Identifying Protein Conformational Dynamics Using Spin‐label ESR, Chemistry - An Asian Journal, 14 (2019) 3981-3991.
B5
 		 Y.H. Kuo and Y.W. Chiang*, Slow Dynamics around a Protein and Its Coupling to Solvent, ACS Central Science, 4 (2018) 645-655.
B6

 		 K.J. Chang+, Y.H. Kuo+, and Y.W. Chiang*, Study of Protein Dynamics under Nanoconfinement by
Spin-Label ESR: A Case of T4 Lysozyme Protein, Journal of Physical Chemistry B, 121 (2017) 4355–
4363.
B7
 		 T.Y. Kao, C.J. Tsai, Y.J. Lan, andY.W. Chiang*, Role of Conformational Heterogeneity in Regulating the Apoptotic Activity of BAX Protein,Physical Chemistry Chemical Physics, 19 (2017) 9584-9591.
B8

 		 YW Huang, YC Lai, CJ Tsai, and YW Chiang*, Mesopores Provide an Amorphous State Suitable for Studying Biomolecular Structure at Cryogenic Temperatures, Proceedings of the National Academy of Sciences (PNAS), 108 (2011) 14145-14150.
 
C. Inorganic/Materials
C1

 		 S.Y. Fu, C.H. Chang, A.S. Ivanov, I. Popovs, J.L. Chen, Y.F. Liao, H.K. Liu, S. Chirra, Y.W. Chiang, J.C. Lee, W.L. Liu, W. Kaveevivitchai*, T.H. Chen*, Mixed-Valence CuI/CuIII Metal−Organic Frameworks with Non-innocent Ligand for Multielectron Transfer, Angew. Chem. Int. Ed., (2023) e202312494.
C2

 		 C. Maitra, P.D. Jadhav, D. Barik, Y.S. Ho, C.C. Cheng, M.J. Cheng*, Y.W. Chiang*, and R.S. Liu*, Nitrosoarenes Implement Cascade Cyclization of 1-Allenyl-2-alkynylbenzenes Through Diradical Mechanism, Organic Letters, 25 (2023) 82-86.
C3

 		 Y.Y. Wu, J.C. Hong, R.F. Tsai, H.R. Pan, B.H. Huang, Y.W. Chiang, G.H. Lee, M.J. Cheng,* and H.F. Hsu*, Ligand-Based Reactivity of Oxygenation and Alkylation in CobaltComplexes Binding with (Thiolato)phosphine Derivatives, Inorganic Chemistry, 59 (2020) 4650-4660.
C4

 		 P. Dai*, Q. Wang, M. Xiang, T.M. Chen, X. Zhang, Y.W. Chiang, T.S. Chan, X. Wang*, Composition-Driven Anionic Disorder-Order Transformations Triggered Single-Eu2+-Converted High-Color-Rendering White-Light Phosphors, Chemical Engineering Journal, 380 (2020) 122508.
C5

 		 C.H. Ke, C.H. Chen, M.L. Tsai, H.C. Wang, F.T. Tsai,Y.W. Chiang, W.C. Shih, D.S. Bohle, and W.F. Liaw*, {Fe(NO)2}9 Dinitrosyl Iron Complex Acting as a Vehicle for the NO Radical, Journal of the American Chemical Society, 139 (2017) 67-70.
C6


 		 C.C. Wang, H.C. Chang, Y.C. Lai, H. Fang, C.C. Li, H.K. Hsu, Z.Y. Li, T.S. Lin, T.S. Kuo, F. Neese, S. Ye*,Y.W. Chiang*, M.L. Tsai*, W.F. Liaw*, and W.Z. Lee*, A Structurally Characterized Nonheme Cobalt-Hydroperoxo Complex Derived from its Superoxo Intermediate via Hydrogen Atom Abstraction, Journal of the American Chemical Society, 138 (2016) 14186-14189.

Full publication list ==> (Link)
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